The Genesis Mission: Transforming Science and Energy with AI
Description
The DOE Office of Science (SC), Office of Critical Minerals and Energy Innovation (CMEI), Office of Environmental Management (EM), Office of Nuclear Energy (NE), Office of Electricity (OE), and Hydrocarbons and Geothermal Office (HGEO) hereby announce interest in receiving applications from interdisciplinary teams addressing the Genesis Mission National Science and Technology Challenges to accelerate scientific discovery and research and development (R&D) workflows using novel artificial intelligence (AI) models and frameworks. By achieving AI advantage, these teams will advance the DOE's mission and ensure Americaโs security and prosperity by addressing energy, environmental, and nuclear challenges through science and technology. Teams are encouraged to leverage the extensive scientific and data resources of the DOE/National Nuclear Security Administration (NNSA), the National Laboratories, U.S. industry, and academia. The resulting AI models and workflows, if successful, may be integrated into the American Science Cloud.
DOE is soliciting new FY26 Phase I small team and Phase II large team applications in the following topic areas: advanced manufacturing, biotechnology, critical materials, nuclear fission, nuclear fusion, quantum information science, semiconductors and microelectronics, discovery science, and energy (see specific focus areas in Section III Program Descriptions).
In addition, this RFA will remain available to allow the recipients of FY26 Phase I awards to apply for larger team Phase II awards. In a few weeks, DOE plans to amend the RFA to clarify the LOI and application guidelines for FY26 Phase II awards. In FY27, DOE plans to amend the RFA or to issue an alternative funding opportunity to update the topic and focus areas to allow a second competition of Phase I small team applications and Phase II large team applications.
Agency: Michael S Zarkin
Grants Management Specialist
CFDA: 81.049
Applicant Types: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled "Additional Information on Eligibility"
Cost Sharing: Yes
Contact: Michael S Zarkin
Grants Management Specialist
Email: GenesisMissionNOFO@science.doe.gov
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About This Opportunity
This is a grants contract in the information and communication technology sector. Located in United States, North America, this opportunity is open to firms and consortiums, with an estimated budget of USD 500,000 โ USD 5.0 million. Proposals must be submitted before December 17, 2026.
Published through Grants.gov, a national government procurement portal. Public procurement tenders follow the country's national bidding regulations and may have specific eligibility and documentation requirements for grants in the information and communication technology sector. Grant applications generally require a detailed project proposal, a clear results framework, and evidence of the applicant's capacity to deliver the proposed activities. Interested parties should review the full documentation on the original source before submitting their proposal.