HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional)
About This Opportunity
This is a grants contract in the health and medical services and Research sectors, with a focus on Pharmaceuticals. Located in United States, North America, this opportunity is open to firms and consortiums. Proposals must be submitted before February 20, 2029.
Published through Grants.gov, a national government procurement portal. Public procurement tenders follow the country's national bidding regulations and may have specific eligibility and documentation requirements for grants in the health and medical services sector. Grant applications generally require a detailed project proposal, a clear results framework, and evidence of the applicant's capacity to deliver the proposed activities. Interested parties should review the full documentation on the original source before submitting their proposal.
Description
The purpose of this Notice of Funding Opportunity (NOFO) is to support the preclinical optimization and development of safe, effective, and non-addictive small molecule and biologic therapeutics for the treatment of pain.
The goal of the program is to accelerate the advancement of promising early-stage therapeutic candidates and facilitate their readiness for Phase II clinical trials. Applicants must have a promising small molecule or biologic lead candidate for optimization, a strong biological rationale for the proposed approach, and established assays to guide the optimization process.
The scope of the program includes lead optimization, early-stage development activities, IND-enabling studies, development of pharmacodynamic and/or target engagement biomarkers, preparation and submission of an Investigational New Drug (IND) application, and Phase I clinical testing. This is a milestone-driven, phased cooperative agreement program that involves active participation by NIH program staff in project planning and ongoing monitoring of research progress.
Agency: National Institutes of Health
CFDA: 93.395, 93.866, 93.839, 93.867, 93.838, 93.846, 93.840, 93.213, 93.273, 93.853, 93.837, 93.233, 93.279, 93.865
Eligible Applicants: Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Applicant Types: Private institutions of higher education; Native American tribal governments (Federally recognized); Small businesses; Others (see text field entitled "Additional Information on Eligibility" for clarification); Public housing authorities/Indian housing authorities; Independent school districts; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Special district governments; City or township governments; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; For profit organizations other than small businesses; Native American tribal organizations (other than Federally recognized tribal governments); State governments; County governments; Public and State controlled institutions of higher education
Cost Sharing: No
Contact: National Institutes of Health
Email: PTDP@ninds.nih.gov
Data provenance
This notice is sourced from Grants.gov and was originally published on June 16, 2026. Last refreshed 2 days ago. BidsFactory mirrors official procurement notices and links back to the source for full legal text.
About National Institutes of Health
National Institutes of Health has issued 79 procurement notices on BidsFactory, including 77 currently open and 0 awarded contracts. Activity concentrates in Health & Medical, Research & Innovation, and Information & Communication Technology. All notices are published for United States. Notices are distributed via Grants.gov. Most recent publication: June 16, 2026.
Frequently asked questions about this tender
How can I submit a bid?
Visit Grants.gov to access the full notice, required documents, and submission instructions provided by the contracting authority.
When does this tender close?
The submission deadline is February 20, 2029. You have 971 days left to prepare and submit your proposal to the contracting authority.
Who is the contracting authority?
This notice was issued by National Institutes of Health in United States. The authority is responsible for evaluating bids, awarding the contract, and managing performance.
What type of contract is this?
This is a Grants contract in the Health & Medical sector. The classification helps bidders match the opportunity to their qualifications and registered scope of supply.
Where will the contract be performed?
The contract is for delivery in United States. Foreign bidders should review local registration, taxation, and any in-country presence requirements before submitting.
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