3626S32273 - Ionizing radiation and its effects on neurodegeneration: Analysis of cellular protein misfolding and protein degradation pathways
About This Opportunity
This is a consulting contract in the health and medical services and Research sectors, with a focus on Laboratory. Located in Germany, Europe, this opportunity is open to firms and consortiums. Proposals must be submitted before August 11, 2026.
Published through DÖE Bekanntmachungsservice (Germany), a national government procurement portal. Public procurement tenders follow the country's national bidding regulations and may have specific eligibility and documentation requirements for consulting in the health and medical services sector. Consulting assignments are typically evaluated with a strong emphasis on the technical proposal, including the methodology and qualifications of key experts. Shortlisted firms may be invited to submit financial proposals in a second stage. Interested parties should review the full documentation on the original source before submitting their proposal.
Description
Auto-translated from GermanIonizing radiation and its effects on neurodegeneration: Analysis of cellular protein misfolding and protein degradation pathways Neurodegenerative diseases such as Alzheimer's and Parkinson's are commonly known as age-related diseases, with significantly increasing incidences worldwide. Several recent epidemiological meta-studies now indicate an additionally increased risk of dementia after low acute or chronic doses of ionizing radiation. The biological basis for the long-term development of neurodegenerative diseases by radiation is still largely unclear. Increased accumulations of denatured proteins in the central nervous system are considered a cellular indicator for dementia diseases, which are presumably developing over decades and are gradually held responsible for the death of large numbers of neurons in the brain. Whether and to what extent ionizing radiation can also contribute to increased denaturation and possibly aggregation of proteins is to be investigated at the cell biological and molecular level in this project. For this purpose, human neuronal cells are exposed to different doses of ionizing radiation to quantify changes in the solubility of the entire proteome. Consequently, disease-relevant protein mutants are expressed in the cells to analyze the influence of ionizing radiation on the aggregation process. Furthermore, the function of radiation-inducible DNA repair and proteasome shuttling factors HR23A/B on protein balance and degradation is to be investigated mass spectrometrically, with a focus on changes in the total proteome after exposure to ionizing radiation in neuronal cell lines, as well as in knockout cell lines of HR23A/B. Finally, the influence of ionizing radiation on the passage of toxic protein oligomers of the Aβ peptide in a blood-brain barrier model is to be investigated. The research results contribute to a better fundamental understanding of potentially radiation-induced neuronal degeneration, as well as to an improvement of risk assessment and prevention.
Data provenance
This notice is sourced from DÖE Bekanntmachungsservice (Germany) and was originally published on July 1, 2026. Last refreshed 19 days ago. Original language: German. BidsFactory mirrors official procurement notices and links back to the source for full legal text.
About Bundesamt für Strahlenschutz (BfS)
Bundesamt für Strahlenschutz (BfS) has issued 3 procurement notices on BidsFactory, including 1 currently open and 0 awarded contracts. Activity concentrates in Health & Medical, Research & Innovation, and Architecture & Engineering Services. All notices are published for Germany. Notices are distributed via DÖE Bekanntmachungsservice (Germany). Most recent publication: July 1, 2026.
Frequently asked questions about this tender
How can I submit a bid?
Visit DÖE Bekanntmachungsservice (Germany) to access the full notice, required documents, and submission instructions provided by the contracting authority.
When does this tender close?
The submission deadline is August 11, 2026. You have 10 days left to prepare and submit your proposal to the contracting authority.
Who is the contracting authority?
This notice was issued by Bundesamt für Strahlenschutz (BfS) in Germany. The authority is responsible for evaluating bids, awarding the contract, and managing performance.
What type of contract is this?
This is a Consulting contract in the Health & Medical sector. The classification helps bidders match the opportunity to their qualifications and registered scope of supply.
Where will the contract be performed?
The contract is for delivery in Germany. Foreign bidders should review local registration, taxation, and any in-country presence requirements before submitting.
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